Scott Foster

Scott Foster

Company: Genentech Inc

Job title: Principal Scientist


[VIRTUAL] Degradation Is Not Always Superior to Enzymatic Inhibition: Lessons Learned from EGFR Heterobifunctional Degraders 4:00 pm

Targeted degradation of EGFR failed to suppress resistance common to EGFR targeted therapies Degradation resulted in decreased efficacy relative to non-degrader controls Comparing degrader vs non-degrader controls highlighted an unexpected role for ER stress contributing to the efficacy of canonical EGFR targeted therapiesRead more

day: Day One

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