[VIRTUAL] Degradation Is Not Always Superior to Enzymatic Inhibition: Lessons Learned from EGFR Heterobifunctional Degraders
Time: 4:00 pm
day: Day One
Details:
- Targeted degradation of EGFR failed to suppress resistance common to EGFR targeted therapies
- Degradation resulted in decreased efficacy relative to non-degrader controls
- Comparing degrader vs non-degrader controls highlighted an unexpected role for ER stress contributing to the efficacy of canonical EGFR targeted therapies
