[VIRTUAL] Degradation Is Not Always Superior to Enzymatic Inhibition: Lessons Learned from EGFR Heterobifunctional Degraders

Time: 4:00 pm
day: Day One


  • Targeted degradation of EGFR failed to suppress resistance common to EGFR targeted therapies
  • Degradation resulted in decreased efficacy relative to non-degrader controls
  • Comparing degrader vs non-degrader controls highlighted an unexpected role for ER stress contributing to the efficacy of canonical EGFR targeted therapies