Targeting Pantothenate Kinase as an Effective Strategy for Antifungal Drug Development
Time: 10:25 am
day: Day Two
Details:
- Pantothenate kinase (PanK) activity is the first step in Co-enzyme A (CoA) biosynthesis. In fungi, a single PanK gene, CAB1, encodes this function
- A high-throughput chemical screen identified fungal PanK inhibitors and the CAB1 3D structure revealed essential residues for catalysis, inhibitor binding, and future SAR studies
- The fungal PanK were validated as targets for antifungal drug development
