Tumor-Selective Targeting of Kinase Conformations For Cancer Therapy
Time: 12:30 pm
day: Day Two
Details:
- Therapeutic effectiveness of targeted cancer therapies is limited by Incomplete inhibition of the target pathway in the tumor caused by various adaptive resistance mechanisms
- Increased drug dosing or vertical drug combinations to overcome resistance are limited by on-target toxicities in normal tissue and low Therapeutic Index
- Improved therapies require drugs and drug combinations that target tumor-selective kinase conformations to achieve both potent antitumor efficacy and a high Therapeutic Index
