David Heppner

David Heppner

Company: University at Buffalo

Job title: Assistant Professor - Medicinal Chemistry


Structural Insights into Emerging Inhibitors Targeting EGFR Mutations 12:00 pm

The structure of lazertinib allows for enhanced potency and mutant selectivity against EGFR T790M Next generation mutant EGFR C797S inhibitors bind the kinase domain through H-bonding with conserved catalytic residues Spanning ATP-allosteric EGFR inhibitors can be developed exhibiting unique kinase domain binding and mutant selectivityRead more

day: Day Two

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