Exploring Inhibitor Selectivity at Multimeric Kinase Complexes in Cells

Time: 9:30 am
day: Day One


  • Redefining kinase inhibitor selectivity in cells with NanoBRET
  • Using a novel structural complementation method, engagement can be observed at select RAF protomers within RAS/RAF signalosome
  • In the presence of mutant KRAS, RAF protomer selectivity drives drug escape mechanisms