Phenocopying IRAK1/4 Inhibition With R289 and Its Translation Into The Clinic Using a prodrug of R835 to inhibit IRAK1/4: R289

Time: 5:00 pm
day: Day One


  • Selectively inhibiting inflammatory innate immune signalling to tissue damage signals (PAMPs/DAMPs/IL-1 family of cytokines) in cells, animals and whole blood assays
  • Profoundly inhibiting inflammatory cytokine production induced by i.v. dosed LPS in healthy volunteers with R835
  • Phase 1 results position R289 attractively with respect to its translational PK/PD data